一、基本信息
刘家书，博士，硕士研究生导师
电子邮件：jsliu@hubu.edu.cn
研究领域：环境微生物学、生物质资源化、生物催化与转化
社会兼职：BioDesign Research青年编委
二、教育背景
2014.09-2020.10 华中科技大学，博士
三、工作经历
2024.09至今 湖北大学，副教授
2023.05-2024.09 湖北大学，讲师
2020.10-2023.05 湖北大学，博士后
四、科研项目
（一）主持项目：
1. 国家重点研发计划子课题：人工多细胞体系活体材料的物质单元设计与合成（2024YFA0919100），2024.12-2029.11，主持。
2. 国家自然科学基金青年基金：漆酶响应氧化胁迫促进短小芽孢杆菌抗氧化耐受增强的分子机制（32100099），2022.1-2024.12，主持。
3. 湖北省工业微生物重点实验室开放基金项目：高效合成2,5-呋喃二甲酸的微生物细胞工厂构建研究（2024KF08），2024.9-2026.9，主持。
4. 特色果蔬质量安全控制湖北省重点实验室开放基金项目：木质纤维素降解复合菌剂的构建及其在堆肥中的应用研究（2024K003），2024.10-2026.10，主持。
5. 湖北大学研究生教育教学改革研究项目：生命科学硕士研究生学位论文质量保障全过程体系的构建（JGYJS202413），2024.7-2026.6，主持。
（二）参与项目：
1. 国家重点研发计划项目：工业酶的智能设计与催化应用（2021YFC2100100），2021.7-2024.6，参与。
2. 省部共建生物催化与酶工程国家重点实验室开放课题项目：生物质对裂解性多糖单加氧酶的诱导调控及酶解增效作用（SKLBEE20230017），2023.12-2025.12，参与。
五、代表性论文（#共同第一作者，*通讯作者）
1. Jiashu Liu#, Jiabao Deng#, Xuemei Tan, Yan Li, Huanan Li, Wanli Cheng, Zhengbing Jiang*. Co-integration of laccase and xylanase from Bacillus pumilus into mini-cellulosome facilitates softwood sulfite pulp biobleaching and reduces hydrogen peroxide consumption. International Journal of Biological Macromolecules, 2025, 290: 139048.
2. Fang Peng#; Jiashu Liu#; Jiapeng Ping; Yuji Dong; Liuan Xie; Yishan Zhou; Lipei Liao; Huiting Song*. An effective strategy for biodegradation of high concentration phenol in soil via biochar-immobilized Rhodococcus pyridinivorans B403. Environmental Science and Pollution Research, 2024, 31: 33752-33762.
3. Bianxia Li; Zhuocheng Jin; Fan Yang; Huanan Li; Jiashu Liu*; Zhengbing Jiang*. Proteomic investigation reveals the role of bacterial laccase from Bacillus pumilus in oxidative stress defense. Journal of Proteomics, 2024, 292: 105047.
4. Fan Yang#; Jiashu Liu#; Bianxia Li; Huanan Li; Zhengbing Jiang*. Effective biosynthesis of 2,5-furandicarboxylic acid from 5-hydroxymethylfurfural via a bi-enzymatic cascade system using bacterial laccase and fungal alcohol oxidase. Biotechnology for Biofuels and Bioproducts, 2023, 16(1): 164.
5. Jianhui Chen#; Jiashu Liu#; Bixin Chen; Fan Yang; Bianxia Li; Huanan Li; Zhengbing Jiang; Huiting Song*. Effective biodegradation of chlorophenols, sulfonamides, and their mixtures by bacterial laccase immobilized on chitin. Ecotoxicology and Environmental Safety, 2023, 256: 114856.
6. Qiuping Ran; Mengtian Huang; Huanan Li; Bixin Chen; Lili He; Xinxin Cui; Jiashu Liu*; Zhengbing Jiang*. A new strategy for cellulases application in high temperature industrial scenarios with syringic acid assisting. GCB Bioenergy, 2023, 15: 821-833.
7. Jiashu Liu; Bianxia Li; Zhuang Li; Fan Yang; Bixin Chen; Jianhui Chen; Huanan Li; Zhengbing Jiang*. Deciphering the alkaline stable mechanism of bacterial laccase from Bacillus pumilus by molecular dynamics simulation can improve the decolorization of textile dyes. Journal of Hazardous Materials, 2023, 443: 130370.
8. Rui Wang; Huanan Li; Yanfang Liu; Jianhui Chen; Fang Peng; Zhengbing Jiang; Jiashu Liu*; Huiting Song*. Efficient removal of azo dyes by Enterococcus faecalis R1107 and its application in simulated textile effluent treatment. Ecotoxicology and Environmental Safety, 2022, 238: 113577.
9. Kangjia Zuo; Huanan Li; Jianhui Chen; Qiuping Ran; Mengtian Huang; Xinxin Cui; Lili He; Jiashu Liu*; Zhengbing Jiang*. Effective biotransformation of variety of guaiacyl lignin monomers into vanillin by Bacillus pumilus. Frontiers in Microbiology, 2022, 13: 901690.
10. Jiashu Liu#; Jianhui Chen#; Kangjia Zuo; Huanan Li; Fang Peng; Qiuping Ran; Rui Wang; Zhengbing Jiang; Huiting Song*. Chemically induced oxidative stress improved bacterial laccase-mediated degradation and detoxification of the synthetic dyes. Ecotoxicology and Environmental Safety, 2021, 226: 112823.
11. Xiaohang Xie#; Jiashu Liu#; Zhengbing Jiang; Huanan Li; Meng Ye; Hong Pan; Jingwei Zhu; Huiting Song*. The conversion of the nutrient condition alter the phenol degradation pathway by Rhodococcus biphenylivorans B403: A comparative transcriptomic and proteomic approach. Environmental Science and Pollution Research, 2021, 28(40): 56152-56163.
12. Jiashu Liu#; Su Sun#; Yuling Han#; Jing Meng; Yang Chen; Hongbo Yu; Xiaoyu Zhang; Fuying Ma*. Lignin waste as co-substrate on decolorization of azo dyes by Ganoderma lucidum. Journal of the Taiwan Institute of Chemical Engineers, 2021, 122: 85-92.
13. Jiashu Liu; Fengjie Liu; Chunlian Ding; Fuying Ma; Hongbo Yu; Yan Shi*; Xiaoyu Zhang*. Response of Trametes hirsuta to hexavalent chromium promotes laccase-mediated decolorization of reactive black 5. Ecotoxicology and Environmental Safety, 2020, 205: 111134.
14. Jiashu Liu#; Shu Zhang#; Qipeng Shi; Lei Wang; Wen Kong; Hongbo Yu*; Fuying Ma*. Highly efficient oxidation of synthetic and natural lignin-related compounds by Physisporinus vitreus versatile peroxidase. International Biodeterioration and Biodegradation, 2019, 136: 41-48.
六、授权专利
1. 宋慧婷，刘家书，张天翼，董羽吉，解留安，一种低碳氮比高氨氮降解菌及其应用，ZL202310431661.9
2. 宋慧婷，江正兵，刘家书，李华南，王瑞，一种偶氮染料降解菌及其应用，ZL202210654954.9
3. 江正兵，冉秋萍，宋慧婷，李华南，刘家书，周樱，一种提高纤维素酶比活力的方法及其应用，ZL202111327122.8
七、获奖
1. 高效复配纤维素酶创制关键技术与应用，2022年湖北省科技进步奖一等奖
