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罗静雯

作者:  发布时间:2025-04-10  阅读次数:

7

一、基本信息

罗静雯,博士,副教授,硕士生导师

电子邮箱:jwluo0227@163.com

研究方向:靶向药物传递系统设计,缓控释给药系统研究,癌症的基因治疗和免疫治疗

招生专业:生物学、生物与医药

二、教育背景

2013.09 – 2019.06 四川大学华西药学院,药剂学,理学博士

2009.09 – 2013.06 武汉科技大学医学院,药学,理学学士

三、工作经历

2021.09 – 至今       湖北大学生命科学学院,副教授

2022.10 – 2024.10 共青团湖北大学委员会,副书记(挂职)

2019.07 – 2021.07 湖北大学生命科学学院,博士后,合作导师:马立新教授

四、主持科研项目

1. 湖北省自然科学基金一般面上项目,2025.03 – 2027.0210万,主持

2. 国家自然科学基金青年基金项目,2021.01 – 2023.1224万,主持

3. 中国博士后特别资助项目(站中),2020.01 – 2021.1218万,主持

4. 中国博士后面上项目(一等资助),2019.10 – 2021.0812万,主持

5. 湖北省科技活动项目择优资助,2019.10 – 2021.086万,主持

6. 湖北大学青年基金,2022.01 – 2023.122万,主持

7. 国家自然科学基金面上项目,2019.01 – 2022.1260万,参与

8. 国家自然科学基金面上项目,2017.01 – 2020.1253万,参与

五、代表性论文(#第一作者; *通讯作者)

1. Zhang S, Li M, Zeng J, Zhou S, Yue F, Chen Z, Ma L, Wang Y*, Wang F* and Luo J*. (2025) Somatostatin receptor-targeted polymeric nanoplatform for efficient CRISPR/Cas9 gene editing to enhance synergistic hepatocellular carcinoma therapy. Journal of Nanobiotechnology 23:127,1-19.

2. Yang X, Zhou S, Zeng J, Zhang S, Li M, Yue F, Chen Z, Dong Y*, Zeng Y*, Luo J*. (2024) A biodegradable lipid nanoparticle delivers a Cas9 ribonucleoprotein for efficient and safe in situ genome editing in melanoma. Acta Biomaterialia  190,531-547.

3. Yang X, Chang L, Lin Q, Wang J, Su P, Chen X, Yi Z, Dong Y*, Luo J*. (2024) Microneedle pretreatment and cationic nanoparticles for transdermal delivery of doxorubicin against melanoma. Journal of Drug Delivery Science and Technology 93,105417.

4. Cai M #, Luo J #, Yang C, et al. (2023) ABHD12 contributes to tumorigenesis and sorafenib resistance by preventing ferroptosis in hepatocellular carcinoma. iScience 26,108340.

5. Cheng Y, Wang C, Wang H, Zhang Z, Yang X, Dong Y, Ma L*, and Luo J*. (2022) Combination of an autophagy inhibitor with immunoadjuvants and an anti-PD-L1 antibody in multifunctional nanoparticles for enhanced breast cancer immunotherapy. BMC medicine 20,411.

6. Luo J #, Zhang Z #, Zeng Y, Dong Y, Ma L. (2021) Co-encapsulation of collagenase type I and silibinin in chondroitin sulfate coated multilayered nanoparticles for targeted treatment of liver fibrosis. Carbohydrate Polymers 263, 117964.

7. Zhang Z, Ma L*, and Luo J *. (2021) Chondroitin Sulfate-Modified Liposomes for Targeted Co-Delivery of Doxorubicin and Retinoic Acid to Suppress Breast Cancer Lung Metastasis. Pharmaceutics 13, 3, 406.

8. Luo J, Gong T, Ma L. (2020) Chondroitin-modified lipid nanoparticles target the Golgi to degrade extracellular matrix for liver cancer management. Carbohydrate Polymers 249, 116887.

9. Luo J, Yin P, Gong T, et al. (2019) Golgi Apparatus-Targeted Chondroitin-Modified Nanomicelles Suppress Hepatic Stellate Cell Activation for the Management of Liver Fibrosis. ACS Nano 13, 3910-3923.

10. Luo J, Zhang P, Gong T, et al. (2019) Efficient weapon for protracted warfare to malaria: a chondroitin sulfate derivates-containing injectable, ultra-long-lasting meshy-gel system. Carbohydrate Polymers 214, 131-141.

11. Luo J, Zhang Z, Gong T, Fu Y. (2016) One-step self-assembled nanomicelles for improving the oral bioavailability of nimodipine. International Journal of Nanomedicine 11, 1051-1065.

12. Luo J, Zhang T, Gong T, et al. (2016) A novel injectable phospholipid gel co-loaded with doxorubicin and bromotetrandrine for resistant breast cancer treatment by intratumoral injection. Colloids and Surfaces B: Biointerfaces 140, 538-547.

13. Zhang T #, Luo J #, Gong T, et al. (2017) Novel oral administrated paclitaxel micelles with enhanced bioavailability and antitumor efficacy for resistant breast cancer. Colloids and Surfaces B: Biointerfaces 150, 89-97.

六、申请与授权专利

1. 罗静雯,周松丽,岳飞凡,陈昭仪,谢星雨,马立新。一种两亲性聚合物、聚合物囊泡及其制备方法和应用。专利号:2025101907033

2. 龚涛,罗静雯,张培,宋旭,张志荣,孙逊。一种载药网状原位相变凝胶缓释系统及其制备方法。专利号:ZL201811171012.5

3. 龚涛,李昊欢,罗静雯,张培,宋旭,张志荣,孙逊。一种高尔基体靶向的粘多糖纳米胶束及其制备方法与应用。专利号:ZL201811521626.1

七、荣誉及奖励

1. 2021年入选湖北省“楚天学子”人才项目

2. 湖北省第十四届“挑战杯”大学生课外学术科技作品竞赛优秀工作者

3. 2023年湖北大学突出贡献奖

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