一、基本信息
高卫杰，博士，讲师
电子邮件：gaowj@hubu.edu.cn；gaoweijiehsd@126.com
研究领域：类器官/工程化微组织构建，心血管疾病模型及致病机理，干细胞与癌症干细胞
二、教育背景
2015.08–2018.10 香港中文大学，生物医学博士
2010.09–2013.07 华南师范大学，生物物理学硕士
2006.09–2010.07 河南师范大学，理学学士
三、工作经历
2023.08 至今 湖北大学，讲师
2020.07–2023.07 中山大学肿瘤防治中心，博士后，合作导师：康铁邦 研究员
2018.11–2020.06 香港中文大学，Research Associate/博士后，合作导师：Prof. Franky Leung CHAN
四、主持科研项目
1. 湖北省自然科学基金计划一般面上项目（JCZRYB202501394），NDRG1调控骨肉瘤干细胞分化机制及诱导分化疗法的研究，2025.3 – 2027.2，10万元，在研，主持
2. 广东省海外博士后人才支持项目，2021-2023, 主持
3. 国家自然科学基金面上项目（32370819），MYBL2-RAN促进骨肉瘤干细胞生长的调控机制及临床意义，2024.01-2027.12，50万元，参与
4. 香港研究资助局 General Research Fund（14107617），Elucidating the role of endothelial nitric oxide synthase (eNOS) in prostate cancer，2018.07-2021.06，101.8万港元，参与
五、代表性论文（#第一作者; *通讯作者）
1. Zhuo Zhang; Hetian Du; Weijie Gao*; Donghui Zhang*; Engineered macrophages: an“Intelligent Repair” cellular machine for heart injury, Cell Regeneration, 2024, 13 (IF: 4.0)
2. Weijie Gao#, Jing Zhou#, Jintao Huang#, Zhiguang Zhang, Wanqi Chen, Ruhua Zhang, Tiebang Kang, Dan Liao, Li Zhong. Up-regulation of RAN by MYBL2 maintains osteosarcoma cancer stem-like cells population during heterogeneous tumor generation. Cancer Lett. 2024; 586:216708 (IF: 9.1 一区Top)
3. Weijie Gao, Yuliang Wang, Shan Yu, Zhu Wang, Taiyang Ma, Andrew M Chan, Peter K Chiu, Chi-Fai Ng, Dinglan Wu, Franky L Chan. Endothelial nitric oxide synthase (eNOS)-NO signaling axis functions to promote the growth of prostate cancer stem-like cells. Stem Cell Res Ther. 2022; 13(1):188. (IF: 7.1)
4. Weijie Gao, Dinglan Wu, Yuliang Wang, Zhu Wang, Chang Zou, Yong Dai, Chi-Fai Ng, Jeremy Y Teoh, Franky L Chan. Development of a novel and economical agar-based non-adherent three-dimensional culture method for enrichment of cancer stem-like cells. Stem Cell Res Ther. 2018; 9(1):243. (IF: 7.1)
5. Taiyang Ma, Wenjuan Xie, Zhenyu Xu, Weijie Gao, Jianfu Zhou, Yuliang Wang, Franky L Chan. Estrogen-related receptor alpha (ERRα) controls the stemness and cellular energetics of prostate cancer cells via its direct regulation of citrate metabolism and zinc transportation. Cell Death Dis. 2025; 16(1):154. (IF: 8.1)
6. Yuliang Wang, Weijie Gao, Youjia Li, Sin Ting Chow, Wenjuan Xie, Xingxing Zhang, Jianfu Zhou, Franky L Chan. Interplay between orphan nuclear receptors and androgen receptor-dependent or-independent growth signalings in prostate cancer. Mol Aspects Med. 2021; 78:100921. (IF: 8.7)
7. Jiayi Zhou, Xiaojuan Pei, Yingui Yang, Zhu Wang, Weijie Gao, …, Dinglan Wu. Orphan nuclear receptor TLX promotes immunosuppression via its transcriptional activation of PD-L1 in glioma. J Immunother Cancer. 2021; 9(4):e001937. (IF: 10.3)
8. Zhenyu Xu, Taiyang Ma, Jianfu Zhou, Weijie Gao, Youjia Li, Shan Yu, Yuliang Wang, Franky L Chan. Nuclear receptor ERRα contributes to castration-resistant growth of prostate cancer via its regulation of intratumoral androgen biosynthesis. Theranostics. 2020; 10(9):4201-4216. (IF: 12.4)
9. Weijie Gao#, Fenglian Xiao#, Xiaoping Wang, Tongsheng Chen. Artemisinin induces apoptosis of A549 cells dominantly via a ROS-mediated positive feedback amplification activation loop among caspase-9, 3 and 8. Apoptosis. 2013; 18 (10): 1201-1213.
10. Fenglian Xiao#, Weijie Gao#, Xiaoping Wang, Tongsheng Chen. Amplification activation loop between caspase-8 and -9 dominates artemisinin-induced apoptosis of ASTC-a-1 cells. Apoptosis. 2012; 17(6):600-11.
七、荣誉及奖励
2024 武汉英才计划（优秀青年人才）
2015-2018 香港中文大学Postgraduate studentships
