一、基本信息
乔玉本，博士，讲师，硕士生导师，学院科研秘书
电子邮件：qiaoyuben12@163.com; yb_qiao@hubu.edu.cn
研究方向：天然药物化学生物学
讲授课程：《生物化学》，《有机化学》，《合成生物学》
学术兼职：中国化学会会员，美国化学会会员，中国药学会会员，湖北省合成生物学会会员
聚焦于活性天然药物挖掘及药效分子合成生物学研究，涉及新化学结构的分离鉴定及生物学活性筛选、功能天然产物分子生物合成途径解析及关键酶的分子改造。在Nat. Catal., ACS Catal., Org. Chem. Front., Org. Lett., J. Agric. Food Chem., J. Nat. Prod., Front. Pharm., Bioorg. Chem., Phytochemistry, Org. Biomol. Chem.,等期刊发表论文30余篇。2024年获得国家留学基金委CSC Scholarship资助，公派前往东京大学从事科学研究。主持国家级及省部级等科研项目5项，参与科研项目多项。担任Org. Lett., J. Mol. Struct., Bioresour Bioprocess., J. Nutr. Biochem., Tetrahedron Lett.等杂志审稿人，硕士学位论文通讯评审专家。
二、教育背景
2015–2020 华中科技大学同济医学院药学院，医学博士，导师：张勇慧教授
2011–2015 华中科技大学同济医学院药学院，药学学士
三、工作经历
2024– 东京大学药学部，特別研究員，合作导师，Ikuro Abe教授
2023– 湖北大学生命科学学院/省部共建生物催化与酶工程国家重点实验室，讲师，团队PI：李爱涛教授
2020–2022 华中科技大学生命科学与技术学院，博士后，合作导师：张勇慧/闫云君教授
2019–2020 中国科学院微生物研究所/微生物资源前期开发国家重点实验室，访问学者
四、获得奖励及荣誉
1. 湖北大学“沙湖学者”计划攻关IV岗（2025）
2. 湖北大学年度教学科研考核优秀（2024）
3. 国家留学基金委CSC Scholarship（2024）
4. 华中科技大学优秀毕业生（2020，2015）
5. 华中科技大学优秀共产党员（2019）
6. 华中科技大学十佳党员（2018）
7. 同济医学院海外校友总会-美捷登生物医学研究生奖学金（2018）
8. 研究生国家奖学金（2017）
五、主要科研项目
1. 国家自然科学基金青年项目，紧密篮状菌中Duclauxins类化合物定向挖掘及其免疫抑制活性研究，2025.01–2027.12，30万元，主持，在研。
2. 湖北省自然科学基金青年项目，最后一步：完整解析聚酮二聚体Epicocconigrone A的生物合成机制，2024.03–2026.03，8万元，主持，在研。
3. 企业技术开发项目，真菌脱水酶BaiE的开发与应用，2024.03–2026.03，10万元，主持，在研。
4. 生物催化与酶工程国家重点实验室开放基金，土曲霉中aspulvinone型木脂素羟基化酶的发现及催化产物构效关系研究，2023.12–2024.12，4万元，已结题。
5. 中国博士后科学基金面上项目，Epicoccingrone A的全生物合成途径解析，2021.09–2023.07，8万元，主持，已结题。
6. 湖北省博士后创新研究岗位基金，Terrein生物合成及关键缩环工具酶开发，2020.10–2022.06，6万元，主持，已结题。
7. 国家重点研发计划“合成生物学”重点专项，组合生物合成构建新骨架人工产物，2022.1–2026.12，参与，在研。
8. 湖北省“创新药物筛选技术研发与集成”科技重大专项，2022.1–2024.12，参与，在研。
9. 国家自然科学基金青年项目，构巢裸胞壳抗NDM-1超级细菌新颖次生代谢产物研究，2019.01–2022.12，21.5万元，参与，已结题。
六、发表论文（#第一作者，*通讯作者）
2025
1 Yuben Qiao#, Ikuro Abe*, Aitao Li*, et al., Submitted to the Journal.
2 Di Deng#, Zhihui Jiang#, Lixin Kang#, Langxing Liao, Xiaodong Zhang, Yuben Qiao, Yang Zhou, Linliu Yang, Binju Wang*, Aitao Li*. An efficient catalytic route in hame peroxygenases mediated by O2/small-molecule reductant pairs for sustainable applications. Nat. Catal., 2025, 8, 20–32.
3 Lixin Kang#, Haoran Li#, Kexin Lin#, Shen Hu, Song Liu, Yuben Qiao, Ying Wang*, Aitao Li*. Regioselectivity switching in CYP107Pdh-catalyzed VD3 hydroxylation: A structure-guided approach to improve calcidiol production. ACS Catal., 2025, 15, 4160−4171.
4 Qianqian Xu#, Yuben Qiao*, et al., In revision.
5 Qianqian Xu, Yuben Qiao, et al., Submitted to the Journal.
6 Xueqi Lan#, Xiaoxia Gu#, Yeting Zhang#, Hong Hu, Zhengyi Shi, Chaohu Xiong, Xinye Huang, Binbin Song, Yuben Qiao*, Weiguang Sun*, Changxing Qi*, Yonghui Zhang*. Discovery of quorum sensing inhibitors against Pseudomonas aeruginosa from Aspergillus sp. NB12. Bioorg. Chem., 2025, 156, 108230.
2024
1 Xueqi Lan#, Yeting Zhang#, Hong Hu, Zhengyi Shi, Xinye Huang, Yuben Qiao*, Changxing Qi*, Yonghui Zhang*. Discovery of Immunosuppressive 30-Norlanostane Triterpenoids and Oleanane Type Triterpenoids from Aspergillus sp. Tj507. SSRN, 2024. doi.org/10.2139/ssrn.4826892.
2 Yeting Zhang#, Jinbing Kang#, Qun Zhou#, Ming Chen, Jinlong Zhang, Zhengyi Shi, Yuben Qiao, Changxing Qi*, Yonghui Zhang*. Discovery of 23,24-diols containing ergosterols with anti-neuroinflammatory activity from Penicillium citrinum TJ507. Bioorg. Chem., 2024, 150, 107575.
3 Yeting Zhang#, Qing Li#, Jinglong Zhang, Ming Chen, Xuan Li, Yuben Qiao, Kuansong Wang*, Changxing Qi*, Yonghui Zhang*. Eurochevalierines A−I, Sesquiterpene Alkaloid Hybrids with Anti-Triple Negative Breast Cancer Activity from Penicillium sp. HZ-5. J. Agric. Food Chem., 2024, 72, 16801–16811.
4 Mengyi Deng, Yan Xiao, Shu Wang, Min Zhang, Yuben Qiao, Shuai Huang, Jiang Xie, Xianli Zhou*. Penicimides A and B, two novel diels–alder [4 + 2] cycloaddition ergosteroids from Penicillium herquei. Bioorg. Chem., 2024, 143, 107025.
2016–2023
1 Yuben Qiao#, Qiaoxin Xu#, Zijian Huang, Xia Chen, Xiaomeng Ren, Wenling Yuan, Zhenhua Guan, Pengkun Li, Fengli Li, Chaomei Xiong, Hucheng Zhu, Chunmei Chen, Lianghu Gu, Yuan Zhou, Changxing Qi, Zhengxi Hu, Junjun Liu*, Ying Ye*, Yonghui Zhang*. Genome Mining Reveals a New Cyclopentane-forming Sesterterpene Synthase with Unprecedented Stereo-control. Org. Chem. Front. 2022, 9, 5808–5818.
2 Yuben Qiao#, Xiaosheng Tan#, Qianqian Xu#, Zijun Zhang, Qiaoxin Xu, Li Tao, Junjun Liu, Hucheng Zhu, Chunmei Chen, Ying Ye, Yuanyuan Lu, Gang Chen*, Changxing Qi*, Yonghui Zhang*. Asperosin A, a [4+2] Diels–Alder cycloaddition polyketide dimer from Aspergillus rugulosa with immunosuppressive activity. Org. Chem. Front. 2022, 9, 2477–2485 (Hot off the Press, Nat. Prod. Rep., 2022, 39, 1117).
3 Mengyi Deng, Xia Chen, Yuben Qiao, Zhengyi Shi, Jianping Wang, Hucheng Zhu, Lianghu Gu, Changxing Qi*, Yonghui Zhang*. Isolation, absolute configurations and bioactivities of pestaphilones A–I: Undescribed methylated side chain containing-azaphilones from Pestalotiopsis oxyanthi. Phytochemistry, 2022, 194, 113045.
4 Mengyi Deng, Xiaosheng Tan, Yuben Qiao, Weiguang Sun, Shuangshuang Xie, Zhengyi Shi, Yuanyuan Lu, Gang Chen*, Changxing Qi*, Yonghui Zhang*. New secondary metabolites from the endophytic fungus Aspergillus sp. from Tripterygium wilfordii. Nat. Prod. Res., 2022, 36, 3544–3552.
5 Xian Shu#, Guangzheng Wei#, Yuben Qiao#, Kexin Zhang, Jun Zhang, Guomin Ai, Man-cheng Tang, Yonghui Zhang, Shu-Shan Gao*. TerC Is a Multifunctional and Promiscuous Flavoprotein Monooxygenase That Catalyzes Bimodal Oxidative Transformations. Org. Lett. 2021, 23, 8947–8951.
6 Qianqian Xu#, Yuben Qiao#, Zijun Zhang, Yanfang Deng, Tianqi Chen, Li Tao, Qiaoxin Xu, Junjun Liu, Weiguang Su, Ying Ye, Yuanyuan Lu*, Changxing Qi*, Yonghui Zhang. New Polyketides with Anti-Inflammatory Activity from the Fungus Aspergillus rugulosa. Front. Pharm., 2021, 12, 700573.
7 Mengyi Deng, Xia Chen, Zhengyi Shi, Shuangshuang Xie, Yuben Qiao, Gang Chen, Xiaosheng Tan, Yuanyuan Lu, Changxing Qi, Yonghui Zhang*. New immunosuppressive secondary metabolites from the endophytic fungus Aspergillus sp. Fitoterapia, 2021, 151, 104882.
8 Mengyi Deng, Li Tao, Yuben Qiao, Weiguang Sun, Shuangshuang Xie, Zhengyi Shi, Changxing Qi, Yonghui Zhang. Fitoterapia, New cytotoxic secondary metabolites against human pancreatic cancer cells from the Hypericum perforatum endophytic fungus Aspergillus terreus. Fitoterapia, 2020, 146, 104685.
9 Shuangshuang Xie, Changxing Qi, Yulin Duan, Xincai Hao, Yi Guo, Mengyi Deng, Yuben Qiao, Zhengyi Shi, Li Tao, Yunfang Cao, Lianghu Gu*, Yuan Zhou*, Yonghui Zhang*. Wilsonglucinols A–C, homoadamantane-type polycyclic polyprenylated acylphloroglucinols with unusual fused epoxy ring skeletons from Hypericum wilsonii. Org. Chem. Front., 2020, 7, 464–471.
10 Mengyi Deng, Yaping Liu, Yingying Huang, Xu Yin, Yuan Zhou, Yulin Duan, Shuangshuang Xie, Yi Guo, Yuben Qiao, Zhengyi Shi, Li Tao, Yunfang Cao, Changxing Qi*, Yonghui Zhang*. New bioactive secondary metabolites from the Anoectochilus roxburghii endophytic fungus Aspergillus versicolor. Fitoterapia, 2020, 143, 104532.
11 Yuben Qiao#, Qianqian Xu#, Wenya Feng, Li Tao, Xiao-Nian Li, Junjun Liu, Hucheng Zhu, Yuanyuan Lu, Jianping Wang, Changxing Qi*, Yongbo Xue*, Yonghui Zhang*. Asperpyridone A: An Unusual Pyridone Alkaloid Exerts Hypoglycemic Activity through the Insulin Signaling Pathway. J. Nat. Prod., 2019, 82, 2925–2930 (Cover).
12 Yulin Duan, Shuangshuang Xie, Yi Guo, Yuben Qiao, Zhengyi Shi, Li Tao, Mengyi Deng, Yunfang Cao, Yongbo Xue*, Changxing Qi*, Yonghui Zhang*. Przewalcyrones A–F, epoxychromene-containing polycyclic polyprenylated acylphloroglucinols with immunosuppressive activity from Hypericum przewalskii Maxim. Org. Biomol. Chem., 2019, 17, 8234–8242.
13 Na Zhang, Zhengyi Shi, Yi Guo, Shuangshuang Xie, Yuben Qiao, Xiao-Nian Li, Yongbo Xue*, Zengwei Luo, Hucheng Zhu, Chunmei Chen, Linzhen Hu, Yonghui Zhang*. The absolute configurations of hyperilongenols A–C: rare 12,13-seco-spirocyclic polycyclic polyprenylated acylphloroglucinols with enolizable β,β′-tricarbonyl systems from Hypericum longistylum Oliv. Org. Chem. Front., 2019, 6, 1491–1502.
14 Yuben Qiao#, Xiaotian Zhang#, Yan He#, Weiguang Sun#, Wenya Feng, Junjun Liu, Zhengxi Hu, Qianqian Xu, Hucheng Zhu, Jinwen Zhang, Zengwei Luo, Jianping Wang*, Yongbo Xue*, Yonghui Zhang*. Aspermerodione, a novel fungal metabolite with an unusual 2,6-dioxabicyclo[2.2.1]heptane skeleton, as an inhibitor of penicillin-binding protein 2a. Sci. Rep., 2018, 8, 5454.
15 Yuben Qiao#, Yanfei Liu#, Xueyan Duan, Chunmei Chen, Junjun Liu, HuchengZhu, YongboXue*, Yonghui Zhang*. A pair of epimeric cassane-type diterpenoids and a new labdane-type derivative from Caesalpinia decapetala. Tetrahedron, 2018, 74, 3852–3857.
16 Yuben Qiao#, Kun Tu#, Wenya Feng, Junjun Liu, Qianqian Xu, Li Tao, Hucheng Zhu, Chunmei Chen, Jianping Wang, Yongbo Xue*, Yonghui Zhang*. Polyketide and Prenylxanthone Derivatives from the Endophytic Fungus Aspergillus sp. TJ23. Chem. Biodivers., 2018, e1800395.
17 Changxing Qi#, Yuben Qiao#, Weixi Gao, Mengting Liu, Qun Zhou, Chunmei Chen, Yongji Lai, Yongbo Xue, Jinwen Zhang, Dongyan Li, Jianping Wang, Hucheng Zhu, Zhengxi Hu, Yuan Zhou*, Yonghui Zhang*. New 3,5-dimethylorsellinic acid-based meroterpenoids with BACE1 and AchE inhibitory activities from Aspergillus terreus. Org. Biomol. Chem., 2018, 16, 9046–9052.
18 Shuangshuang Xie, Ye Wu, Yuben Qiao, Yi Guo, Jianping Wang, Zhengxi Hu, Qing Zhang, Xiaonian Li, Jinfeng Huang, Qun Zhou, Zengwei Luo, Junjun Liu, Hucheng Zhu, Yongbo Xue*, Yonghui Zhang*. Protoilludane, Illudalane, and Botryane Sesquiterpenoids from the Endophytic Fungus Phomopsis sp. TJ507A. J. Nat. Prod., 2018, 81, 1311–1320.
19 Yuben Qiao#, Qianqian Xu#, Zhengxi Hu, Xiao-Nian Li, Ming Xiang, Junjun Liu, Jinfeng Huang, Hucheng Zhu, Jianping Wang, Zengwei Luo, Yongbo Xue*, Yonghui Zhang*. Diterpenoids of the Cassane Type from Caesalpinia decapetala. J. Nat. Prod. 2016, 79, 3134–3142.
七、专利
1. 张勇慧，何艳，乔玉本，李琴，朱虎成，胡正喜，薛永波，汪建平。真菌次生代谢产物中具有抗菌活性化合物的分离制备及用途，中国专利，ZL201710951372.6
