一、基本情况
阳姹，博士，特任副研究员
电子邮箱：flying25@126.com
研究领域：免疫代谢在大脑衰老中的调控机制
二、教育背景
2012.09-2018.12 华中农业大学 动科动医学院，农学博士
2008.09-2012.06 湖南农业大学 东方科技学院，农学学士
三、工作经历
2026.03至今 湖北大学 生命科学学院，特任副研究员
2023.09-2025.03美国康奈尔大学 威尔细胞与分子生物学研究所，Research Associate
2019.09-2023.08美国康奈尔大学 威尔细胞与分子生物学研究所，博士后
四、科研项目
1. 康奈尔大学博士后研究项目，Induction of TDP-43 cytoplasmic puncta formation by DNA molecules，
2020.9-2023.8，主持
2. NIH R21，Investigating the role of progranulin in TDP-43 proteinopathy，2022.7-2024.6，参与
3. NIH R01，Function of TMEM106B in neurodegeneration，2021.4-2026.3，参与
4. 国家自然科学基金面上项目，核仁蛋白LYAR调控流感病毒复制的分子机制研究，2018.1.1-
2021.12.31，参与
五、发表论文 （*第一作者）
1. Yang C*, Du H*, Lee GB, Uematsu M, Doré E, He W, Yu W, Sanford E, Baskin J, Smolka M, Boilard E, Smolka M, Baskin J, Hao L, and Hu F. sPLA2-IIA modifies progranulin deficiency phenotypes in mouse models. Molecular Neurodegeneration. (2025) 20:72. https://doi.org/10.1186/s13024-025-00863-8.
2. Liu X*, Yang C*, Lin X, Sun X, Chen H, Zhang Q, Jin M. Phosphorylation of S-S-S Motif in Nuclear Export Protein (NEP) Plays a Critical Role in Viral Ribonucleoprotein (vRNP) Nuclear Export of Influenza A and B Viruses. Adv Sci. 2024 Nov 22:e2309477. doi: 10.1002/advs.202309477.
3. Yang C, Liu Y, Hu F. IκB kinase thwarts aggregation: Phosphorylating TDP-43 for degradation. Journal of cell biology. 2024 Feb 5;223(2):e202311176. https://doi.org/10.1083/jcb.202311176.
4. Yang C, Leifer C, Lammerding J, and Hu F. Regulation of TAR DNA binding protein 43 (TDP-43) homeostasis by cytosolic DNA accumulation. J Biol Chem. 2024 Dec;300(12):107999. doi: 10.1016/j.jbc.2024.107999.
5. Yang C, Liu X, Cheng T, Xiao R, Gao Q, Ming F, Jin M, Chen H, Zhou H. LYAR suppresses beta interferon induction by targeting phosphorylated interferon regulatory factor 3. Journal of virology. 2019. doi: 10.1128/JVI.00769-19.
6. Yang C, Liu X, Gao Q, Cheng T, Xiao R, Ming F, Zhang S, Jin M, Chen H, Ma W, Zhou H. The nucleolar protein LYAR facilitates ribonucleoprotein assembly of influenza A virus. Journal of virology. 2018. doi: 10.1128/jvi.01042-18.
7. Yang C, Lee GB, Hao L, Hu F. TMEM106B deficiency leads to alterations in lipid metabolism and obesity in the TDP-43Q331K knock-in mouse model. Commun Biol. 2025 Feb 26;8(1):315. doi: 10.1038/s42003-025-07752-2.
8. Yang, C., Feng, T. & Hu, F. Progranulin deficiency does not exacerbate TDP-43 pathology in TDP-43 transgenic mouse models. npj Dement. 1, 16 (2025).
9. Liu X*, Yang C*, Sun X, Lin X, Zhao L, Chen H, Jin M. Evidence for a novel mechanism of influenza A virus host adaption modulated by PB2-627. FEBS Journal. 2019. doi: 10.1111/febs.14867.
10. Liu X*, Yang C*, Hu Y, Lei E, Lin X, Zhao L, Zou Z, Zhang A, Zhou H, Chen H, Qian P, Jin M. HIST1H1C regulates interferon-beta and inhibits influenza virus replication by interacting with IRF3. Frontiers in Immunology. 2017 Mar, doi: 10.3389/fimmu.2017.00350.
11. Lee GB, Yang C, Hao L, Hu F. Evaluating sample normalization methods for MS-based multi-omics and the application to a neurodegenerative mouse model. Analyst. 2025 Feb 25. doi: 10.1039/d4an01573h.
12. Feng T, Du H, Yang C, Wang Y, Hu F. Loss of TMEM106B exacerbates Tau pathology and neurodegeneration in PS19 mice. Acta Neuropathologica. 2024 Mar 25;147(1):62.
13. Cheng H, Miller D, Southwell N, Fischer J, Taylor I, Salbaum J, Kappen C, Hu F, Yang C, Gross S, D’Aurelio M, Chen Q. Untargeted Pixel-by-Pixel Imaging of Metabolite Ratio Pairs as a Novel Tool for Biomedical Discovery in Mass Spectrometry Imaging. eLife. 2025 Feb 20, https://doi.org/10.7554/eLife.96892.2
14. Gao Q, Jiang M, Zhao Y, Li G, Yang C, Ren C, et al. eIF4A3 Promotes RNA Viruses' Replication by Inhibiting Innate Immune Responses. J Virol. 2022;96(22): e0151322.
15. Gao Q, Yang C, Ren C, Zhang S, Gao X, Jin M, et al. Eukaryotic Translation Elongation Factor 1 Delta Inhibits the Nuclear Import of the Nucleoprotein and PA-PB1 Heterodimer of Influenza A Virus. J Virol. 2020;95(2).
